DENISAR PALMITO DOS SANTOS,DIEGO PATRICK SOARES LOPES,ROBSON AMARO AUGUSTO DA SILVA
申请号：
BR102017024693
公开号：
BR102017024693A2
申请日:
2017.11.17
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
This invention refers to the use of the extract of myrciaria cauliflora activated by light LED Blue against Staphylococcus aureus. In this context, photodynamic therapy (tfd) emerges as a promising technology through microbial inactivation with the use of light. TFD involves the use of non -toxic dyes called photosensitisers, or light -sensitive substances that are activated when exposed to a specific visible wavelength specific to their activation. Thus, with the intense use of antimicrobials And the possibility of bacterial resistance, natural products are studied as alternatives,Such as the use of plant extract. M. Cauliflora has antimicrobial potential due to antocyanins, phenolic compounds present in its husks and seeds. Therefore, this work brought a new approach to the use of the extract of M. Cauliflora, in association with TFD, activated by blue LED light (led bluephase, ivoclar Vivadent, Liechtenstein, 380 -515 nm wavelength, 1200 MW /cm2 intensity over five minutes) in the treatment of infection Bacterial reaction caused by S. Aureus. Inhibition of bacterial growth in vitro as well as in vivo has been observed. In addition,It has been observed that animals treated with extract of M. Photoactivated cauliflora reduces the production of IL -17, IL -10, IL -5, IL -4 and IL -1beta,And increases the production of TNF -a.a presente invenção refere-se a utilização do extrato de myrciaria cauliflora ativado por luz led azul contra staphylococcus aureus. neste contexto, a terapia fotodinâmica (tfd) surge como uma tecnologia promissora através da inativação microbiana com o uso da luz. a tfd envolve a utilização de corantes não tóxicos, denominados fotossensibilizadores, ou substancias sensíveis a luz que são ativadas quando expostas a determinado comprimento de onda de luz visível específico para sua ativação. diante disso, com a intensa utilização de antimicrobianos e a possibilidade de resistência bacteriana, produtos naturais são estudados como alternativas, com
