The present invention provides treatment of fatty liver disease using a class of pyrimidinedione cyclohexyl compounds. In one embodiment, the present invention provides a method of treating fatty liver disease. The method includes administering to a subject in need thereof, a therapeutically effective amount of a compound of Formula I, thereby treating the fatty liver disease, wherein the compound of Formula I has the structure (I).La présente invention concerne le traitement de la stéatose hépatique au moyen dune classe de composés de cyclohexyle pyrimidinedione.