A system and method for preventing the movement of emboli away from a vascular region. The system generally includes a medical device having a clot capture assembly, a shaft, and a sheath disposed about the shaft, and a console. The clot capture assembly includes a first and second clot capture element, each of which is disposed between the shaft and sheath when in a first position. When the sheath is retracted, the first and second clot capture elements expand into a second position, at least a portion of the first and second clot capture elements being substantially in contact with at least a portion of an interior surface of a section of vasculature.