John R. MacDougall,Juan Guillermo Paez,Karen J. McGovern,Jeffery L. Kutok,Georgios Skliris,Kerry White,Kerrie L. Faia,Marisa Osswalt Peluso,Veronica Travaglione Campbell
申请号：
US14455760
公开号：
US20150025012A1
申请日:
2014.08.08
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided herein are methods, assays and kits for evaluating a sample, e.g., a sample obtained from a cancer patient, to detect one or more hedgehog biomarkers and/or one or more cilium markers. Thus, the invention can be used, inter alia, as a means to identify patients likely to benefit from administration of one or more hedgehog inhibitors, alone or in combination with therapeutic agents to predict a time course of disease or a probability of a significant event in the disease of a cancer patient to stratify patient populations and/or to more effectively treat or prevent a cancer or a tumor associated with hedgehog signaling.
