Robert PETIT,Kyle PERRY,Michael F. PRINCIOTTA,Daniel J O'CONNOR
申请号：
US15576178
公开号：
US20190381160A1
申请日:
2016.05.26
申请国别(地区):
US
年份:
2019
代理人:
摘要：
This invention provides a system of providing and creating personalized immunotherapeutic compositions for a subject having a disease or condition, including therapeutic immunotherapy delivery vectors and methods of making the same comprising gene expression constructs expressing peptides associated with one or more neo-epitopes or peptides containing mutations that are specific to a subject's cancer or unhealthy tissue. A delivery vector of this invention includes bacterial vectors including Listeria bacterial vectors； or viral vectors, peptide immunotherapy vectors； or DNA immunotherapy vectors, comprising one or more fusion proteins comprising one or more peptides comprising one or more neo-epitopes present in disease-bearing biological samples obtained from the subject. This invention also provides methods of using the same for inducing an immune response against a disease or condition, including a tumor or cancer, or an infection, or an autoimmune disease or an organ transplant rejection in the subject.
