The Board of Trustees of Western Michigan Univeraity
发明人:
Karim Essani,David Jeng,Steven J. Conrad
申请号：
US16594630
公开号：
US20200114024A1
申请日:
2019.10.07
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A composition for treating cancerous cells in a subject having an immune system includes a virus in the Yatapoxvirus genus having at least one mutation. In one embodiment, the mutation results in suppressed expression of a TNF binding protein by the virus. In another embodiment, the mutation results in suppressed expression of thymidine kinase (“TK”) by the virus. In another embodiment, the mutation arms the virus with a transgene to express a bacterial flagellin. The mutations can be present singly or in combination. Additional aspects include a method of treating cancerous cells with a composition as described herein, and a method of delivering at least one gene to cancerous cells in a subject.
