MODIFIED DNASE AND USES THEREOF

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专利权人:

Protalix Ltd.

发明人:

Lilach CHEN ZELTSBURG,Ilya RUDERFER,Avidor SHULMAN,Liat FUX,Yulia UGORTSEV,Hagit NETA,Sivan GELLEY,Elad LAVEE LAVIAD,Yoseph SHAALTIEL

申请号：

US15540264

公开号：

US20180112201A1

申请日:

2016.01.04

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Modified DNase I protein in which one or more amino acids of a DNase I protein are modified non-cellularly, are provided. The modified DNase I protein exhibits a DNA hydrolytic activity in the presence of actin and an improved DNA hydrolytic activity compared to a homologous non-modified DNase I protein. Processes of preparing the modified DNase I protein and uses thereof in, for example, reducing a DNA content in sputum and/or in treating a disease or condition associated with excess extracellular DNA in a fluid, secretion or tissue of a subject, are also provided.

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中国工程科技知识中心

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http://www.ckcest.cn/home/