Provided is a glucagon-like peptide 2 (GLP-2) analogue or a pharmaceutically acceptable salt thereof, wherein said analogue comprises an amino acid sequence represented by the general formula: R1-Z1-His-Gly-X3-Gly-X5-Phe-X7-Ser-Glu-X10-X11-Thr-Ile-Leu-Asp-X16-Leu-Ala-Ala-Arg-Asp-Phe-Ile-X24-Trp-Leu-IIe-X28-Thr-Lys-X31-X32-X33-Z2-R2 with defined substituents.