SCHOENMAKERS, RONALD,WEBER, WILFRIED,GITZINGER, MARC,FUSSENEGGER, MARTIN,TIGGES, MARCEL,SCHNEIDER, PETER
申请号：
HK12107097.3
公开号：
HK1166280B
申请日:
2012.07.19
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
The invention relates to a pharmaceutical composition comprising a compound of formula (1) wherein R1 is optionally substituted phenyl, optionally substituted pyridyl or optionally substituted indolyl； R2 is (CH2)n wherein n is 0, 1, 2, 3 or 4； R3 is (CH2)mR3A wherein m is 0, 1, 2, 3 or 4, and R3A is methyl, isopropyl, tert-butyl, OCH3, OH, optionally substituted phenoxy, C&equiv；CH, C&equiv；N, optionally substituted phenyl, furanyl or thienyl； A is a ring containing X1 with the meaning O, S, NH, N(CH3) or CH2； and X2 is O, S or NH； and a compound of formula (2) wherein R4 is optionally substituted phenyl, optionally substituted pyridyl, optionally substituted indolyl, &mdash；NR7R8； or &mdash；NH&mdash；N&boxH；CH&mdash；R9； and substituents R5 to R9 have the meanings indicated in the description, in particular ethionamide. The pharmaceutical composition is useful, e.g., in the treatment of multidrug-resistant tuberculosis.
