DISCLOSED IS A METHOD FOR MAINTAINING INDUCED REMISSION OF AN IMMUNE DISEASE, WHICH CAN ALLEVIATE OR REDUCE ANY SERIOUS SIDE EFFECT AND THE BURDENS EXERTED ON A PATIENT SUFFERING FROM THE SAME. THE METHOD COMPRISES CARRYING OUT THE REMISSION INDUCTION FOR AN IMMUNE DISEASE BY THE USE OF A BIOLOGICAL AGENT OR A NUCLEIC ACID SYNTHESIS-INHIBITORY AGENT AND THEN USING AN AGONIST FOR SPHINGOSINE-1-PHOSPHATE RECEPTOR TO THE PATIENT.