Methods and Compositions for Enhancing T Cell Function and Survival

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专利权人:

Inc.;Augusta University Research Institute

发明人:

Samir N. Khleif,Mikayel Mkrtichyan

申请号：

US15422706

公开号：

US20170216355A1

申请日:

2017.02.02

申请国别(地区):

US

年份:

2017

代理人:

摘要：

It has been discovered that the inhibition of PI3K-δ, but not PI3K-α or PI3K-β, delays the terminal differentiation of CD8 T cell and maintains the TCM phenotype thus enhancing their proliferative ability and survival while maintaining their cytokine and Granzyme B production ability. Methods and compositions for delaying or inhibiting terminal differentiation of CD8 T cells are provided.

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中国工程科技知识中心

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http://www.ckcest.cn/home/