Sigma Aldrich Company; Inc.;Sangamo BioSciences;Sangamo BioSciences, Inc.
发明人:
Cui, Xiaoxia,Geurts, Aron M.,Urnov, Fyodor
申请号:
AU2009322964
公开号:
AU2009322964B2
申请日:
2009.12.03
申请国别(地区):
AU
年份:
2014
代理人:
摘要:
Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.