XU WEI,WANG YONG,MAC MORRISON,TESFAI ZEROM,BAJJALIEH WILLIAM,BANNEN LYNNE CANNE,MARLOWE CHARLES K.,KEARNEY PATRICK,NUSS JOHN M.,BROWN S. DAVID
申请号：
NZ60866706
公开号：
NZ608667A
申请日:
2006.10.09
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed herein are N-(3-amino-quinoxalin-2-yl)-sulfonamide derivatives of formula I, wherein the substituents are defined within the specification, compositions comprising said compounds and use of such compounds in the treatment of cancer, particularly breast cancer, colon cancer, rectal cancer, endometrial cancer, gastric carcinoma, glioblastoma, hepatocellular carcinoma, small cell lung cancer, non-small cell lung cancer, melanoma, ovarian cancer, cervical cancer, pancreatic cancer, prostate carcinoma, acute myelogenous leukaemia (AML), chronic myelogenous leukaemia (CML) or thyroid carcinoma. Particularly disclosed is tautomer of N-(3-{ [(3-{ [2-chloro-5-(methoxy)phenyl]amino} quinoxalin-2-yl)amino]sulfonyl} phenyl)-2-methylalaninamide which is represented by formula shown herein.
