Jonathan Schneck,Sean OHerrin,Michael S. Lebowitz,Abdel Hamad
申请号：
US13369429
公开号：
US20120141482A1
申请日:
2012.02.09
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Extracellular domains of transmembrane heterodimeric proteins, particularly T cell receptor and major histocompatibility complex proteins, can be covalently linked to the heavy and light chains of immunoglobulin molecules to provide soluble multivalent molecular complexes with high affinity for their cognate ligands. The molecular complexes can be used, inter alia, to detect and regulate antigen-specific T cells and as therapeutic agents for treating disorders involving immune system regulation, such as allergies, autoimmune diseases, tumors, infections, and transplant rejection.
