LANGERMANN, SOLOMON,YAO, SHENG,OVERSTREET, MICHAEL GLEN,LIU, LINDA
申请号：
CA2894879
公开号：
CA2894879A1
申请日:
2013.12.19
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
B7-H4 specific antibodies and compositions and methods of use thereof are disclosed. The antibodies can be specific for endogenous B7-H4 polypeptides, recombinant B7-H4 proteins and fusions thereof, or combinations thereof. Methods of using B7-H4 specific antibodies to reduce an inflammatory response, or to treat an inflammatory or autoimmune disease/disorders are also disclosed. The antibodies can be administered to a subject to reduce the levels of cell-free B7-H4 in the subject, or reduce cell-free B7-H4 blockage of B7-H4-mediated signal transduction. In some embodiments the antibodies are administered in combination with a B7-H4-Ig fusion protein that mimics transmembrane B7-H4. Preferably, the antibody binds cell-free B7-H4, without binding to the co-administered B7-H4-Ig fusion protein. Methods of diagnosis, determining therapeutic efficacy, and selecting patients for treatment are also disclosed.
