PROBLEM TO BE SOLVED: To provide a solid pharmaceutical preparation stabilizing not only the content of a drug but also an appearance thereof in a solid pharmaceutical preparation comprising the drug destabilized when losing water of crystallization.SOLUTION: The stabilized solid pharmaceutical preparation has a main drug layer containing a granule or a fine granule containing the drug destabilized when losing the water of crystallization and a water-soluble polymer and a coating layer containing the water-soluble polymer and a glucide and formed on the main drug layer.COPYRIGHT: (C)2008,JPO&INPIT【課題】結晶水を失うと不安定化する薬物を含有する固形製剤においてその薬物含量のみならず外観も安定化された固形製剤の提供。【解決手段】結晶水を失うと不安定化する薬物および水溶性高分子を含有する顆粒または細粒を含有する主薬層と、該主薬層上に形成された水溶性高分子および糖質を含有する被覆層とを有する安定化された固形製剤。【選択図】なし
