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Inhibition of crystal growth of roflumilast
专利权人:
Arcutis; Inc.
发明人:
Osbourne, David W.
申请号:
AU2018282098
公开号:
AU2018282098A1
申请日:
2018.06.04
申请国别(地区):
AU
年份:
2019
代理人:
摘要:
Roflumilast crystals have been shown to increase in size during storage. The size of the roflumilast crystals can affect the bioavailability and efficacy of a pharmaceutical composition. The growth of roflumilast crystals can be inhibited during storage by including hexylene glycol in the composition. The resulting composition has improved bioavailability and efficacy and can be used to inhibit phosphodiesterase 4 in patient in need of such treatment.
来源网站:
中国工程科技知识中心
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