Substituted cyclopenta pyrimidine bicyclic compounds having antimitotic and/or antitumor activity and methods of use thereof

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专利权人:

Duquesne University of the Holy Spirit

发明人:

Aleem Gangjee

申请号：

US15453953

公开号：

US10577377B2

申请日:

2017.03.09

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present invention provides substituted cyclopenta and cyclopentyl pyrimidine bicyclic compounds of Formula III,and pharmaceutically acceptable salts, prodrugs, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/