Derivatives of imidazole compounds FUSED Heterocycles as inhibitors of diacylglycerol acyltransferase 2； Pharmaceutical composition that is useful for the treatment of Type I and II diabetes, coronary heart disease, arthritis, Stroke, Alzheimer's disease, among others.
WANG JIAN,AHN KAY,BOEHM MARKUS,CABRAL SHAWN,CARPINO PHILIP A.,FUTATSUGI KENTARO,HEPWORTH DAVID,KUNG DANIEL W.,ORR SUVI
申请号：
CL2014002541
公开号：
CL2014002541A1
申请日:
2014.09.25
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
Derivatives of purine, 3H-imidazo[4,5-b]pyrimidine and 1H-imidazo[4,5-d]pyrazine of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.COMPUESTOS DERIVADOS DE IMIDAZOL FUSIONADO CON HETEROCICLOS, COMO INHIBIDORES DE DIACILGLICEROL ACILTRANSFERASA 2； COMPOSICION FARMACEUTICA QUE LOS COMPRENDE, UTIL PARA EL TRATAMIENTO DE DIABETES TIPO I Y II, ENFERMEDAD CARDIACA CORONARIA, ARTRITIS, TROMBOSIS, ALZHEIMER, ENTRE OTRAS ENFERMEDADES.
