Systems and method for acoustic detection using flow sensors are provided. One system includes a flow conduit configured to allow fluid flow therethrough and a flow disrupter configured to impart a flow disturbance to the fluid flow. The system also includes at least one of a first sensor or a second sensor. The first sensor is disposed within the flow conduit at a first position, wherein the first sensor is responsive to first disturbances and configured to generate signals characteristic of the first disturbances. The second sensor is disposed within the flow conduit at a second position, wherein the second sensor is responsive to second disturbances and configured to generate signals characteristic of the second disturbances. The system additionally includes a processor operably coupled to the first and second sensors, wherein the processor is configured to distinguish between signals characteristic of the first and second disturbances.