ICHAN SCHOOL OF MEDICINE AT MOUNT SINAI;MEMORIAL SLOAN KETTERING CANCER CENTER;MERGHOU;THE SIMONS CENTER FOR SYSTEMS BIOLOGY AT THE INSTITUTE FOR ADVANCED STUDY;WOLCHOK, JEDD D.;BALACHANDRAN, VINOD P.
发明人:
BALACHANDRAN, VINOD P.,WOLCHOK, JEDD D.,MERGHOUB, TAHA,CHAN, TIMOTHY A.,LAESSIG, MICHAEL,LUKSZA, MARTA,LEVINE, ARNOLD J.,GREENBAUM, BENJAMIN D.,LEACH, STEVEN D.
申请号：
CA3050109
公开号：
CA3050109A1
申请日:
2018.01.18
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Systems and methods for determining the likely responsiveness of a human cancer subject to a checkpoint blockade immunotherapy regimen are provided. Sequencing reads are obtained from samples from the subject representative of the cancer. A human leukocyte antigen type and a plurality of clones is determined from the sequencing reads. For each clone, an initial frequency Xa in the one or more samples is determined and a corresponding clone fitness score of the clone is computed, thereby computing clone fitness scores. Each such fitness score is computed by identifying neoantigens in the respective clone, computing a recognition potential for each neoantigen, and determining the corresponding clone fitness score of the respective clone as an aggregate of these recognition potentials. A total fitness, quantifying the likely responsiveness of the subject to the regimen, is computed by summing the clone fitness scores across the plurality of clones.
