It includes the method for reducing the adverse effect (TIAE) of therapy induction that the present invention provides a kind of for treating, including adversely affecting (CIAE) caused by chemotherapy, such as cardiovascular adverse effects (CICAE) caused by peripheral neuritis caused by chemotherapy (CIPN) and/or chemotherapy, incude in the processed subject of anti-cancer active ingredient in one CIAE- of NCS-1- protective compositions by facilitating the pharmaceutically effective dose of subject one. Additionally provide relevant pharmaceutical composition, diagnosis and screening technique.