Provided is a hyaluronic acid (HA) composition for use in treating or preventing mucosa related disorders or diseases including a mixture of HAs having different average molecular weights and different rheological, isolation, tissue scaffold and degradation properties. The resulting formulation demonstrates an optimal balance between adhesion, tissue scaffold and treating time on the treatment and prevention of mucosa related disorders or diseases including conjunctivitis, otitis, allergic rhinitis, gingivitis, oral ulcer, bronchitis, gastroesophageal reflux disease (GERD), esophagitis, gastritis, enteritis, peptic ulcer, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), urethritis, cystitis and vaginitis.本發明係提供一種玻尿酸混合物用於製造治療或預防黏膜相關病變或疾病之組成物的用途,該玻尿酸混合物包含具有不同平均分子量及不同流變(rheology)、分離(isolation)、組織支架(tissue scaffold)及降解性(degradation)之玻尿酸混合物。其劑型之運用被證實在治療及預防黏膜相關病變或疾病上附著、組織支架及治療時間之間可取得適當的平衡。該黏膜相關病變或疾病包括結膜炎、耳炎、過敏性鼻炎、牙齦炎、口腔潰瘍、支氣管炎、胃食管逆流症(gastroesophageal reflux disease,GERD)、食道炎、胃炎、腸炎、消化性潰瘍、發炎性腸疾(inflammatory bowel disease,IBD)、刺激性腸症候群(irritable bowel syndrome,IBS)、尿道炎、膀胱炎和陰道炎。
