DONMIENNE DOEN MUN LEUNG,JIANGHUAI XU,JIRONG LU,LING LIU,YING TANG
申请号：
BR112016023635
公开号：
BR112016023635A2
申请日:
2015.05.12
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present invention relates to compounds that bind to human vascular endothelial growth factor receptor-2 (vegfr2) and to human angiopoietin-2 (ang2), and may be useful for the treatment of cancer, especially solid tumors. induced by vegfr2 and ang2, including gastric cancer, hepatocellular carcinoma, ovarian cancer, colorectal cancer, non-small cell lung cancer, biliary tract cancer, and breast cancer.a presente invenção refere-se a compostos que se ligam ao receptor-2 do fator de crescimento endotelial vascular humano (vegfr2) e à an-giopoietina-2 humana (ang2), e podem ser úteis para o tratamento de câncer, especialmente tumores sólidos induzidos por vegfr2 e ang2, incluindo câncer gástrico, carcinoma hepatocelular, câncer de ovário, câncer colorretal, câncer de pulmão de células não pequenas, câncer do trato biliar, e câncer de mama.
