Thomas Matthew Baker,Matthew Colin Thor Fyfe,Geraint Jones,Stephen Malcolm Thom
申请号：
US15604258
公开号：
US10125100B2
申请日:
2017.05.24
申请国别(地区):
US
年份:
2018
代理人:
摘要：
There are provided compounds of formulas III and VIIa:or a salt or protected derivative thereof, wherein Z2 represents a structural fragment of formula V,wherein R1A to R1E, R2 to R4, R5a, L and X1 to X3 have meanings given in the description, which compounds have antiinflammatory activity, for example through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes； Syk kinase； and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
