Present invention is related to an actuating device for surgical clip having an actuating device body. A fixture head is moveably mounted on a front end of the actuating device body. An opening is deposited around the actuating device body. The fixture head has a lid to cover the opening. Two blocks are respectively mounted on the front end and a rear end of the actuating device body. A trigger is configured to the actuating device body where a connecting rod is deposited between the trigger and the blocks. The present invention is operated by inserting a clip unit into the fixture head securely. A rear end of the clip unit is fixed with the blocks. The present invention is able to be actuated by users triggering the trigger on the actuating device body. The present invention is re-useable for the clip unit being repeatedly installed on the actuating device body.一種血管施夾器的驅動裝置,是在一容置艙體前端可移動地定位結合一固定頭,在該容置艙體的周圍設有一置入開口,該固定頭延伸設有遮蔽該置入開口的置入開口蓋,在該容置艙體內的前、後位置設有兩結合塊,在該容置艙體樞接一扳機,在該板體與兩結合塊之間設有一連桿組件;本發明使用時是將一現有的施夾單元插入該固定頭定位,當該固定頭定位結合在該容置艙體時,該施夾單元後端部的控制端與兩結合塊結合,接著使用者壓動該扳機控制該施夾單元的前端進行夾合動作,由於本發明能重複安裝施夾單元使用,因此具有重複使用驅動裝置的功效。