3.4 - dihidroisoquinolina substituted Compounds, inhibitors of PRMT5 Kit； pharmacist； Pharmaceutical Composition and method of inhibiting PRMT5 method to treat； gene expression； method to alter the transcription； method of treatment of a disorder, such as cancer, diabetes Teas and obesisdad, among others.
CHESWORTH RICHARD,DUNCAN KENNETH W.,BORIACK-SJODIN PAULA ANN,MUNCHHOF MICHAEL JOHN,JIN LEI
申请号：
CL2015001790
公开号：
CL2015001790A1
申请日:
2015.06.19
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
Described herein are compounds of Formula (), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.<；p>；LA SOLICITUD SE REFIERE A COMPUESTOS DERIVADOS DE DIHIDRO Ú； TETRAHIDROISOQUINOLINA, INHIBIDORES PRMT5, A UNA COMPOSICIÓ；N FARMACÉ；UTICA QUE LOS COMPRENDE, A UN KIT FARMACÉ；UTICO QUE LO CONTIENE Y A SUS USOS EN EL TRATAMIENTO DEL CÁ；NCER, TRASTORNOS METABÓ；LICOS O SANGUÍ；NEO<；/p>；
