Lynn DOUCETTE-STAMM,Gordon W. DUFF,Kenneth S. KORNMAN
申请号：
US15404733
公开号：
US20170198350A1
申请日:
2017.01.12
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides stratification methods and kits to identify whether an individual having an inflammation-related disorder has genotype-specific differential expression of IL-1, i.e., is a “high” or “low” producer of IL-1, such that s/he can be provided an appropriate anti-inflammatory drug and at an appropriate dose. The stratification of high or low IL-1 producers is used to guide assignment of different drug doses and therefore reduce drug toxicity and adverse events in an individual who, without stratification, may be prescribed a higher dose than needed to manage the primary indication. The use of IL-1 stratification of drug dosing would allow a better clinical benefit-risk appraisal in an individual patient.
