STUIBLE, MATTHEW,TREMBLAY, GILLES BERNARD,SULEA, TRAIAN,MORAITIS, ANNA N.,FILION, MARIO
申请号：
CA2928851
公开号：
CA2928851A1
申请日:
2013.07.17
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Antibodies and antigen binding fragments that specificallybinds to Siglec-15 are described herein. These antibodies or antigen bindingfrangents may have the ability of inhibiting differentiation of osteoclastsand/or the ability of inhibiting the bone resorption activity of osteoclasts.Compositions and cells expressing anti-Siglec-15 antibodies or antigenbinding fragments are also disclosed herewith. Anti-Siglec-15 antibodiesmay also be useful for the treatment of bone loss, or bone diseases. Methodsfor the detection or diagnosis of bone loss or bone-related diseases are alsodescribed.
