The present invention relates to a method for preparing a compound of formula [I], wherein said method comprises: (i) (a) a compound of formula [II], (b) a compound of formula [III] and (c) 1, Forming a reaction mixture comprising 2-propanediol or polyethylene glycol, or a mixture thereof, and optionally (d) a base； (ii) heating the reaction mixture to a temperature of at least about 150 ° C. A compound of formula [I]； (iii) isolating the compound of formula [I]； and (iv) optionally converting the compound of formula [I] to a salt form. [II] + formula [III] → formula [I] wherein R1 and R2 are each independently H, alkyl or haloalkyl； R3 and R4 are each independently H, alkyl, haloalkyl Or aryl； 5 is alkyl, alkenyl, cycloalkyl or cycloalkyl-alkyl, each of which may be optionally substituted with one or more OH groups； R6 is cyclopropylamino, cyclopropylmethyl Selected from amino, cyclobutylamino, cyclobutylmethylamino and formula (A), wherein one of X, Y and Z is N and the remainder is CR9； R7, R8 and each R9 is independently H , Alkyl or haloalkyl, and at least one of R7, R8 and R9 is other than H. Another aspect of the invention is a method for the preparation of compounds of formula [III], a high diastereoselection method, a method for preparing intermediates of formula [II], and the synthesis of compounds of formula [I]. And other intermediates, as well as methods for preparing crystalline tartrate and the free base of the compound of formula [I]. [Formula 1] [Formula 2]本発明は、式［Ｉ］の化合物を調製するための方法に関し、前記方法が、（ｉ）（ａ）式［II］の化合物、（ｂ）式［III］の化合物及び（ｃ）１，２－プロパンジオール又はポリエチレングリコール、又はそれらの混合物、及び任意選択で（ｄ）塩基を含む反応混合物を形成するステップ；（ii）前記反応混合物を少なくとも約１５０℃の温度に加熱して、式［Ｉ］の化合物を形成するステップ；（iii）前記式［Ｉ］の化合物を単離するステップ；及び（iv）任意選択で前記式［Ｉ］の化合物を塩の形態に変換するステップ；の式［II］＋式［III］→式［Ｉ］のステップを含み、式中：Ｒ１及びＲ２が、それぞれ独立にＨ、アルキル又はハロアルキルであり；Ｒ３及びＲ４が、それぞれ独立にＨ、アルキル、ハロアルキル又はアリールであり；Ｒ５が、アルキル、アルケニル、シクロアルキル又はシクロアルキル－アルキルであり、それらの各々が、任意選択で１又は２以上のＯＨ基と置換されていてもよく；Ｒ６が、シクロプロピルアミノ、シクロプロピルメチルアミノ、シクロブチルアミノ、シクロブチルメチルアミノ及び式（Ａ）から選択
