VETMAN TATIANA NATALI,BLANCO-PILLADO MARIA-JESUS,FISHER MATTHEW JOSEPH,KUKLISH STEVEN LEE
申请号：
NZ70189413
公开号：
NZ701894A
申请日:
2013.06.20
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
The present invention provides a compound of the Formula II, wherein A is one of the four substructures shown in the accompanying figure； R1 is CH3, CF3, or F； R2 is H, CH3, or F； R3 is CH3, OCH3, OH, F； R4 is OH or CH2OH； and X is CH or N； or a pharmaceutically acceptable salt thereof. These compounds are selective EP4 inhibitors and are useful for the treatment of inflammatory conditions such as arthritis.
