A detergent composition, a method of making the detergent composition, and a method of use thereof are provided. The detergent composition comprises at least 0.001% by weight of an antimicrobial agent, based on the total weight of the composition; an enzyme; and at least 0.01% by weight of a hydrotrope, based on the total weight of the composition.本發明提供一種清潔劑組合物、製造該清潔劑組合物之方法及使用其之方法。該清潔劑組合物包含以組合物之總重量計之至少0.001重量%之抗微生物劑;酶;及以組合物之總重量計之至少0.01重量%之增溶物。