Gjalt W. Huisman,Joyce Liu,Nikki Dellas,Chinping Chng,William Casey Hallows
申请号：
US16436176
公开号：
US20190376097A1
申请日:
2019.06.10
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity and enhanced acid stability, while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
