Cannula and scope cleaning apparatus and associated methods of use are provided which allow for the clearing/cleaning of a cannula and cleaning of a viewing scope during a medical procedure, wherein the apparatus can be configured such that the viewing scope need not be removed from within the cannula in order for debris and/or fogging to be removed from a lens portion of the scope. In particular embodiments, the cannula and scope cleaning apparatus can be deformable, having an adjustable lumen therein such that when the apparatus can be disposed within a cannula, viewing scopes having various outside diameter sizes can be slidably introduced and stabilized within a cannula.