LAU, Johnson Yiu-Nam,VERONE-BOYLE, Alissa Rae,WONG, Chun-Ho,BU, Yahao,CUTLER, Murray John,BELKO, Krista Elizabeth,KWAN, Min-Fun Rudolf
申请号：
AU2019231706
公开号：
AU2019231706A1
申请日:
2019.03.06
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
Compositions and methods are provided that are effective in treating skin hyperproliferative disorders. These include a topical pharmaceutical preparation that includes a compound that has two or more of a SRC-kinase inhibiting activity, a tubulin polymerization inhibiting activity, an activity that arrests the cell cycle at G2/M, and an activity that induces apoptosis. The compound KX01 is provided as an example of such a compound. The topical pharmaceutical preparation further includes a vitamin D derivative or a retinoid, where the combination provides a synergistic effect. Use of the topical pharmaceutical preparation can be combined with exposure to blue, UVA, or UVB light, which provides a synergistic effect.
