Pathogen infection and infestation can be controlled in humans, animals and plants by contacting the pathogen with an effective amount of a combination of a plant defensin or a functional natural or synthetic derivative or variant thereof and a non-defensin peptide. Pathogen contamination in environmental locales can also be controlled. The combination of the defensin and peptide are synergistic compared to the use of each alone at the same individual dose as used in the combination. The combinations can be presented in agents and natural and synthetic formulations and extracts.
