KLAUS DR. BENKE,HEIKE DR. NEUMANN,WOLFGANG DR. MCK
申请号：
ARP130102318
公开号：
AR091621A1
申请日:
2013.06.28
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
The Presentation of oral Solid Pharmaceutical containing 5 - chloro N ({(5S) - 2 - oxo - 3 - [4 - (3 - 4 - oxo - morfolinii) - phenyl] - 3 - methyl - 5 - oxazolidin il}) - 2 - (tiofen - carboxamide (Active Principle (i) rivaroxaban) wherein a partial quantity of active Principle (i) is released r u00e1pidamen You and a partial quantity is released in a controlled manner (Modified, delayed Slow)And also to processes for their preparation, their application as medicine, as well as its use for secondary prophylaxis, prophylaxis or treatment of diseases.Claim 1: Presentation of oral Solid pharmaceutical use chlorine - containing 5 - (N - {(5S) - 2 - oxo - 3 - [4 - (3 - oxo 4-morpholinyl) phenyl] - 1.3 - oxazolidin} - il - 5 - methyl - 2 - tiofen) - carboxamide (i) characterized in that it consists of a combination of Rapid Release and controlled, with The dose of active principle Incorporated released in a controlled manner in a bicameral System, Osmotic,And combining the Osmotic Release System with a film Coating with a Content of active principle of Rapid Release of active Principle (i) or a granular or powder coated with active substance content (Tablet Core Coated).Una forma de presentación farmacéutica sólida de uso oral que contiene 5-cloro-N({(5S)-2-oxo-3-[4-(3-oxo-4-morfoliniI)-fenil]-1,3-oxazolidin-5-il}metil)-2-tiofen-carboxamida (principio activo (I) rivaroxaban) caracterizada porque una cantidad parcial del principio activo (I) se libera rápidamente y una cantidad parcial se libera en forma controlada (modificada, retardada, lenta), así como también a procedimientos para su preparación, a su aplicación como medicamento, así como también a su uso para la profilaxis, la profilaxis secundaria o el tratamiento de enfermedades. Reivindicación 1: Forma de presentación farmacéutica sólida de uso oral que contiene 5-cloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-tiofen-carboxamida (I) caracterizada porque se compone de una combin
