John Mervyn David Storey,James Peter Sinclair,Colin Marshall,Han Wan Tan,Claude Michel Wischik
申请号：
US15000723
公开号：
US09555043B2
申请日:
2016.01.19
申请国别(地区):
US
年份:
2017
代理人:
摘要：
This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiaziniumcompounds”) including Methythioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS)； nitrosyl reduction (NR)； thiosulfonic acid formation (TSAF)； oxidative coupling (OC)； Cr(VI) reduction (CR)； isolation and purification of zwitterionic intermediate (IAPOZI)； ring closure (RC)； chloride salt-formation (CSF)； one of: sulphide treatment (ST)； dimethyldithiocarbamate treatment (DT)； carbonate treatment (CT)； ethylenediaminetetraacetic acid treatment (EDTAT)； organic extraction (OE)； and recrystallization (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases.
