A support, positioning and handling device for surgical equipment and instruments such as, for instance, drills, comparators, or resection guides, for arthroplasty operations, in particular for distal femur and/or proximal tibia resection. The device comprises a plurality of linear guides and an angular guide which make it possible to determine the position and angle of operation of the surgical instrument, while also allowing to move it with an extreme accuracy. The plurality of guides guarantees a three-dimensional displacement and inclination of a tool-holder turret, which holds an instrument-holder arm which features an engagement surface with the instrument inclined by a predetermined amount, in order to vary the inclination of the latter.The device allows to perform the arthroplasty surgery without having to drill intramedullary holes, reducing trauma to the patient.