BIFTU, TESFAYE,比夫杜 泰斯菲,CHEN, PING,陈平,陳平,COX, JASON M.,考克斯 杰森Ｍ,考克斯 傑森Ｍ,WEBER, ANN E.,韦伯 安Ｅ,韋伯 安Ｅ,比夫杜 泰斯菲,考克斯 杰森M,考克斯 傑森M,韦伯 安E,韋伯 安E
申请号：
TW098137972
公开号：
TWI398443B
申请日:
2009.11.09
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.本發明係關於新穎的結構式I之經取代胺基四氫哌喃，其係二肽基肽酶IV抑制劑且其可用於治療或預防其中涉及二肽基肽酶IV之疾病，例如，糖尿病且尤其是II型糖尿病。本發明亦係關於包含該等化合物之醫藥組合物及該等化合物及組合物在預防或治療該等其中涉及二肽基肽酶IV之疾病中的用途。
