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Phenyl alkanoic acid derivatives as GPR agonists
专利权人:
Piramal Enterprises Limited
发明人:
Kumar, Sanjay,Sharma, Rajiv,Mahajan, Vishal Ashok,Sawargave, Sangameshwar Prabhakar
申请号:
AU2013227266
公开号:
AU2013227266A1
申请日:
2013.02.27
申请国别(地区):
AU
年份:
2014
代理人:
摘要:
The present invention relates to phenyl alkanoic acid derivatives (the compounds of Formula (I)); and their isotopic forms, stereoisomeric and tautomeric forms and mixtures thereof in all ratios, or pharmaceutically acceptable salts, pharmaceutically acceptable solvates, prodrugs, polymorphs, N-oxides, S-oxides or carboxylic acid isosteres thereof. The invention also relates to processes for the preparation of compounds of Formula (I) and pharmaceutical compositions comprising one or more of the compounds of Formula (I). The said compounds and the pharmaceutical composition function as GPR (G-protein coupled receptor) agonists, particularly as GPR40 agonists, and are useful in the treatment of diseases or conditions mediated by GPR40. The present invention further relates to a method of treatment of diseases or conditions mediated by GPR40comprising administering to a subject in need thereof a therapeutically effective amount of the compounds of Formula (I).
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中国工程科技知识中心
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