The present invention provides a methods and compositions for treating a host afflicted with a Flaviviridae infection, including hepatitis C infection, or in need of reduction of viral protease activity, comprising administering an effective antiviral amount of a derivative of andrographolide alone or in combination or alternation with another antiviral compound.本發明提供一種治療罹患黃熱病毒科病毒(Flaviviridae)感染(包括C型肝炎感染)或需要降低病毒蛋白酶活性之宿主之方法與組成物,其包括單獨投予有效抗病毒量之穿心蓮內酯(andrographolide)衍生物,或與另一種抗病毒化合物組全或交替使用。
