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MOLECULES FIXATRICES D'ANTIGENES PRESENTANT UNE AFFINITE DE FIXATION DU RECEPTEUR DE FC ET UNE FONCTION EFFECTRICE ACCRUES
专利权人:
GLYCART BIOTECHNOLOGY AG
发明人:
UMANA, PABLO,BRUNKER, PETER,FERRARA, CLAUDIA,SUTER, TOBIAS,PUNTENER, URSULA,MOSSNER, EKKEHARD
申请号:
CA2544865
公开号:
CA2544865C
申请日:
2004.11.05
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
The present invention relates to antigen binding molecules (ABMs). Inparticular embodiments, the present invention relates to recombinantmonoclonal antibodies, including chimeric, primatized or humanized antibodiesspecific for human CD20. In addition, the present invention relates to nucleicacid molecules encoding such ABMs, and vectors and host cells comprising suchnucleic acid molecules. The invention further relates to methods for producingthe ABMs of the invention, and to methods of using these ABMs in treatment ofdisease. In addition, the present invention relates to ABMs with modifiedglycosylation having improved therapeutic properties, including antibodieswith increased Fc receptor binding and increased effector function.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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