PROBLEM TO BE SOLVED: To provide a safety inhibitor for aggregation of a protein which has an infinitely small influence on a structure or activity of a protein, inhibits an aggregation of a protein, and can prepare a protein solution with low viscosity, consisting of a specific peptide surfactant.SOLUTION: Provided is an aggregation inhibitor which reduces the viscosity of a protein solution comprising a peptide represented by a sequence of AAAAAAK. The inhibitor for aggregation of a protein uses the peptide in the aqueous solution with a concentration of 0.05 to 1%. Furthermore, a pharmaceutical preparation comprises the aggregation inhibitor of the protein.COPYRIGHT: (C)2015,JPO&INPIT【課題】タンパク質の構造や活性に与える影響が限りなく低くタンパク質の凝集を抑制し、粘度の低いタンパク質溶液を調製できる、特定のペプチド界面活性剤からなる、安全なタンパク質の凝集抑制剤の提供。【解決手段】AAAAAAKの配列で表されるペプチドを含む、タンパク質溶液の粘度を下げる凝集抑制剤。該ペプチドを0.05~1%濃度の水溶液で用いるタンパク質の凝集抑制剤。さらに、前記タンパク質の凝集抑制剤を含む、医薬品。【選択図】図1
