DU, SEAN XIAOHAN,GE, JUN,ZHUANG, XIAOQIAN,ZHOU, TONG,LI, JIANQIANG,SONG, CUILING,SUN, YING,WANG, MEIJU,GU, YUE,SUN, HONGLIN,XU, ZHENXING,HUANG, HONGYING,CHEN, XIAOXIAO
申请号：
EP14765662
公开号：
EP2974740A4
申请日:
2014.02.26
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
Disclosed is a composition comprising: i) HBsAg, a fragment thereof, a variant thereof, or the mixture of at least two of them, ii) HBcAgl-X, a fragment thereof, a variant of the antigen or the antigen fragment, or the mixture of at least two of them, wherein X is an integer of from 149 to 183, iii) CpG-ODN, 21 bases long, which is a phosphorothioate oligonucleotide and includes two or more copies of 5'-NTCGTT-3' motifs. The use of the composition in the treatment of HBV-infection and HBV-induced diseases, and the therapy methods of HBV-infection and HBV-induced diseases are also disclosed.
