The present invention provides a safety self-destroying disposable syringe,whichconsists of a hollow tube, a plunger fitting into the inside of the hollowtube and a rubberpis-ton attached on the tip end of the plunger, and a needle holder attachedon the front end of thehollow tube, wherein said needle holder is comprised of a cone base and aseat; said conebase has a Roll cone for fitting into the needle, and a circular base forfitting into the inside ofthe hollow tube, there are several O-rings attached on the contacting surfacebetween them;there is a locating ring-groove built on the inside wall of the hollow tubeapproaching thefront end for catching up the needle holder; said plunger has a conical headbuilt on the frontend, and said conical head has a circular barb built on the middle portion.The safety syringeprovided by the present invention can be withdrew into the inside of the tube,and also suit tomatch to diversity of standard needles for replacing, it also has simplestructure, easymanu-facturing and convenient use with high safeness features.