Dong, Yizhou,Love, Kevin Thomas,Langer, Robert S.,Anderson, Daniel Griffith,Chen, Delai,Chen, Yi,Vegas, Arturo Jose,Alabi, Akinleye,Zhang, Yunlong
申请号：
AU2017265103
公开号：
AU2017265103B2
申请日:
2017.11.23
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
#$%^&*AU2017265103B220191128.pdf#####ABSTRACT Described herein are compounds and compositions that are characterized by the Markush formulae (I), (II), (III), (IV), (V), and (VI) underneath, where at least one terminal amino group is further functionalized by bearing a group of type (i), (ii), or (iii). Such compounds are obtained by reacting a terminal or internal amino group with epoxides, acrylates, or aldehydes bearing lipophilic groups. The resulting amino acid, peptide, polypeptide-lipids (named "APPLs" in the application) are deemed useful as drug delivery systems including nucleotide delivery to cells. Formulae (i), (ii), and (iii). See Fig. 1.WO 2013/063468 PCT/US2012/062222 1/4 E £~ ~ ~-L3-0>；1O ..... Z aLa-A C) gW a.... zLV-A2$io a；9 9L3-NNO 0 -)i~ aL h'AVO aiLa->；iiO 12Z a -ASO ZaLB-AAO z O-QALOid WL ------- $L OOOG~id ...... ZL3-AAO z v->；mli E Zc a 3W Z L3>；i Ad L Z aLB-ANdZaLa-H z (01a a-H Ca C-Z La-v joiaua [GAO- U191~d IIJ GaJUvGN SUBTITTE HEE (RLa26
