A drug packaging device (10) includes a dispensing portion (20) and a packaging portion (60). The dispensing portion (20) includes a first dispensing portion (22) including a plurality of drug cassettes (26) and a second dispensing portion (24) configured to receive drugs, which are prepared separately from the drugs stored in the first dispensing portion (22), and to dispense the drugs. The second dispensing portion (24) includes a first receiving/dispensing portion (32) and a second receiving/dispensing portion (34). The second receiving/dispensing portion (34) is configured to dispense drugs by the amount required for packaging among a plurality of drugs having been collectively distributed. The first receiving/dispensing portion (32) and the second receiving/dispensing portion (34) are vertically arranged.