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dihydrotetraazabenzoazulenes alkylcyclohexyl ethers
专利权人:
F. Hoffmann-la Roche AG
发明人:
Patrick Schnider
申请号:
BRPI0921058
公开号:
BRPI0921058A2
申请日:
2009.11.09
申请国别(地区):
BR
年份:
2018
代理人:
摘要:
The present invention is concerned with alkylcyclohexylethers of dihydro-tetraazabenzoazulenes, i.e. alkylcyclohexylethers of 5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene s of formula I wherein R1, R2 and R3 are as described herein, their manufacture, and pharmaceutical compositions containing them. The compounds according to the invention act as V1a receptor modulators, and in particular as V1a receptor antagonists. The compounds are useful as therapeutics acting peripherally and centrally in the conditions of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior.
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中国工程科技知识中心
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