COMPOSITION POUR PRÉVENIR OU TRAITER LA FIBROSE PULMONAIRE COMPRENANT COMME PRINCIPE ACTIF UN EXOSOME ISSU DE CELLULES SOUCHES DÉRIVÉES DU TISSU ADIPEUX
CHO, Yong Woo,CHOI, Ji Suk,YEOM, Seung Ho,JUNG, Youn Jae
申请号：
EP17837254
公开号：
EP3494977A4
申请日:
2017.08.03
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present disclosure relates to a composition for preventing or treating pulmonary fibrosis, containing an exosome isolated from an adipose-derived stem cell as an active ingredient, a use of the exosome in preparation of a pharmaceutical for preventing or treating pulmonary fibrosis and a method for preventing pulmonary fibrosis, including a step of administering a pharmaceutical composition containing the exosome as an active ingredient to a subject. The exosome isolated from an adipose-derived stem cell according to the present disclosure contains growth factors related to the treatment of pulmonary fibrosis, such as HGF (hepatocyte growth factor) and IL-10, and can significantly reduce the fibrotic region in a pulmonary fibrosis-induced test animal model. Therefore, it can be usefully used in prevention or treatment of pulmonary fibrosis. In addition, in the treatment of pulmonary fibrosis using the exosome according to the present disclosure, there is little concern of side effects caused by steroid-based drugs and antioxidants used in typical treatment of pulmonary fibrosis and the exosome can be delivered naturally to the lungs through injection, inhalation, etc. Therefore, pulmonary fibrosis can be treated conveniently and economically.
